1.
Org Lett
; 23(16): 6237-6241, 2021 08 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34339206
RESUMO
The direct Pd-catalyzed ß-C-H arylation of aldehydes and ketones was developed by using 2-amino-N,N'-diisopropylsuccinamide as a novel transient directing group (TDG). The TDG showed good versatility in functionalizing unactivated ß-C-H bonds of aldehydes and ketones. It was effective not only for aliphatic aldehydes and ketones but also for aromatic aldehydes and ketones. Besides, it was applicable to o-methylbenzaldehydes.