RESUMO
After a 2-week washout period, 30 elderly hypertensive patients were treated with pindolol (a beta-adrenergic blocker) for 3 weeks. In 13 patients the reduction in blood pressure was satisfactory and treatment with pindolol was continued for another 4 weeks. In 17 patients the subsequent treatment was supplemented with clopamide (a diuretic) for 4 weeks; in 6 the results were satisfactory. Side effects were few and mild.
Assuntos
Clopamida/uso terapêutico , Hipertensão/tratamento farmacológico , Pindolol/uso terapêutico , Idoso , Clopamida/administração & dosagem , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pindolol/administração & dosagemRESUMO
A study was carried out to evaluate the long-term effects and side-effects of a combination product containing the beta-blocker pindolol (10 mg) and the diuretic clopamide (5 mg) in 15 patients with moderate hypertension. All patients completed the 2-years' study. The dose of the combination was increased until blood pressure normalized or a maximum dose of 3 tablets (equivalent to 30 mg pindolol and 15 mg clopamide) daily was reached. Blood pressure and heart rate were recorded monthly and detailed medical examinations were done regularly throughout the study. A mean dose of 2 tablets of the combination product (20 mg pindolol and 10 mg clopamide) produced a significant reduction in blood pressure. In all but 1 patient, blood pressure control was achieved and maintained. No tolerance developed. Heart volume showed a marked decrease. No side-effects of clinical importance were noted.
Assuntos
Clopamida/uso terapêutico , Hipertensão/tratamento farmacológico , Pindolol/uso terapêutico , Adulto , Pressão Sanguínea/efeitos dos fármacos , Combinação de Medicamentos , Eletrocardiografia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Placebos , Potássio/sangue , Fatores de TempoRESUMO
A large, open, multi-centre study was carried out in general practice to evaluate the effectiveness and tolerance of a combination of 10 mg pindolol plus 5 mg clopamide, in single tablet form, in the treatment of patients with essential hypertension. Computer analysis of the records of 8989 patients who completed the 8-weeks' study period showed that treatment with the combination product, in a dosage of 1 tablet daily in 83% of the patients, resulted in excellent blood pressure control in the majority (75%) of cases, irrespective of age or previous antihypertensive treatment, and was particularly effective in those with mild to moderate hypertension who had previously not received any therapy. Side-effects were generally not troublesome and only 8.3% of patients stopped treatment for this reason. The most commonly reported side-effects were dizziness, nausea, tiredness and headache.
Assuntos
Clopamida/uso terapêutico , Hipertensão/tratamento farmacológico , Pindolol/uso terapêutico , Adolescente , Adulto , Idoso , Envelhecimento , Pressão Sanguínea/efeitos dos fármacos , Ensaios Clínicos como Assunto , Clopamida/efeitos adversos , Combinação de Medicamentos , Feminino , Humanos , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Pindolol/efeitos adversosRESUMO
To characterize the haemodynamic effects of diuretics, betablockers and the association of both, 24 hypertensive patients, stages I-II WHO criteria, were studied. Two haemodynamic studies were performed, before under placebo and after two month of active drug therapy. Seven patients received propranolol (PPL) (160-240 mg/day); 7 patients, hydrochlorothiazide (HCT) (150-100 mg/day), and 10 a combined fixed dose of pindolol (PDL) and clopamide (CLP): PDL 10 mg, CLP 5 mg per tablet, each patient receiving one to three tablets according blood pressure response. The haemodynamic study was performed with percutaneous intravenous flow-directed. Swan-Ganz catheter, associated with direct puncture of femoral artery and measuring cardiac output by thermodilution. Arterial pressure was significantly reduced on PPL (p less than 0.05) and PDL-CLP (p less than 0.01) groups, but not in the HCT group. The cardiac index was reduced by PPL (p less than 0.05) but not by HCT and PDL-CLP. The systemic vascular resistance was only reduced in the PDL-CLP group (p less than 0.05). The use of a betablocker with intrinsic sympathetic activity (ISA) (pindolol) in association with a thiazide diuretic (clopamide) seems to induce a favourable change in systemic resistance without a deleterious change in cardiac output as occurred with propranolol.
Assuntos
Clopamida/farmacologia , Hemodinâmica/efeitos dos fármacos , Hidroclorotiazida/farmacologia , Hipertensão/tratamento farmacológico , Pindolol/farmacologia , Propranolol/farmacologia , Clopamida/uso terapêutico , Combinação de Medicamentos , Humanos , Hidroclorotiazida/uso terapêutico , Hipertensão/fisiopatologia , Pindolol/uso terapêutico , Propranolol/uso terapêutico , Distribuição AleatóriaRESUMO
The case is reported of a 16 year-old girl with arterial hypertension, generalized neurofibromatosis, coarctation of the abdominal aorta, bilateral renal artery stenosis, occlusion of the coeliac artery and superior mesenteric artery and kyphoscoliosis.
Assuntos
Coartação Aórtica/complicações , Arteriopatias Oclusivas/complicações , Artéria Celíaca , Hipertensão Renovascular/complicações , Cifose/complicações , Artérias Mesentéricas , Neurofibromatose 1/complicações , Escoliose/complicações , Adolescente , Clopamida/uso terapêutico , Feminino , Humanos , Hipertensão Renovascular/tratamento farmacológico , Metildopa/uso terapêutico , Pindolol/uso terapêuticoRESUMO
In 35 patients with mild essential hypertension the influence of 9 week Viskaldix therapy on hemodynamics was evaluated. Twelve of them underwent repeated hemodynamic examinations after mean 13 months treatment. Viskaldix therapy lowered total peripheral resistance --TPR and there was no significant influence on the heart rate, stroke volume, and cardiac output. It was demonstrated that decrease of total peripheral resistance after treatment with Viskaldix was directly proportional to the initial values of TPR.
Assuntos
Anti-Hipertensivos/uso terapêutico , Clopamida/administração & dosagem , Clopamida/uso terapêutico , Hemodinâmica/efeitos dos fármacos , Hipertensão/tratamento farmacológico , Pindolol/administração & dosagem , Pindolol/uso terapêutico , Adulto , Combinação de Medicamentos , Hemodinâmica/fisiologia , Humanos , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-IdadeRESUMO
The therapeutic efficacy of combined and separate application of a diuretic (brinaldix) and beta-adrenoblocker (visken) was compared in the treatment of 69 patients with essential hypertension running a stable course; the patients were kept on a low-sodium diet (4-6 g NaCl daily) and given a potassium substitute for NaCl.
Assuntos
Clopamida/uso terapêutico , Dieta Hipossódica , Hipertensão/terapia , Cloreto de Potássio/uso terapêutico , Adulto , Idoso , Pressão Sanguínea/efeitos dos fármacos , Diurese/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Seguimentos , Humanos , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Pindolol/uso terapêutico , Potássio/metabolismo , Sódio/metabolismoRESUMO
The possibility of treating resistant forms of cardiac insufficiency by a combination of furosemide and brinaldix was studied. The efficacy of the diuretics was appraised with reference to diurnal diuresis, sodium-potassium- and chloruresis on the days of taking the diuretics. In making investigations the method of dispersion analysis (permutation trial test) was used. The final results show that the proposed combination (80 mg of furosemide and 40 mg of brinaldix) is effective and warranted in dealing with patients resistant to many diuretics including furosemide. The action of this combination continues for a long time in the presence of signs of cardiac incompetence and is not accompanied by the development of a marked hypokalemia.