A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis
Marques, Julia Hatagami; Talib, Leda Leme; Hortêncio, Lucas; Andrade, Julio Cesar; Alves, Tania Maria; Serpa, Mauricio Henriques; Yamamoto, Guilherme Lopes; van de Bilt, Martinus Theodorus; Rössler, Wulf; Gattaz, Wagner Farid; Loch, Alexandre Andrade.
Braz. J. Psychiatry (São Paulo, 1999, Impr.);
45(3): 268-273, May-June 2023. tab, graf
Artigo
em Inglês
|
LILACS-Express
| ID: biblio-1447583
Resumo
Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5 years, and conversion to psychotic and to general psychiatric disorders was assessed. Genotype frequencies between controls, converters, and non-converters were analyzed. Results: There were no differences in sociodemographics between controls and UHR. Also, UHR converters and non-converters had no differences in their baseline symptoms scores. The dopamine receptor D2 gene (DRD2) SNP rs6277 was significantly more common among UHR who transitioned to psychosis (p < 0.001) and to UHR who transitioned to any psychiatric disorders (p = 0.001) when compared to UHR who did not transition. The rs6277 T allele was related to psychiatric morbidity in a dose-response fashion, being significantly more frequent in UHR converters than UHR non-converters and control subjects (p = 0.003). Conclusion: Our findings suggest that rs6277 could potentially constitute a genetic marker of transition to psychiatric disorders in subjects with at-risk mental states, warranting further investigation in larger samples.
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