Full-speed mammalian genetics: in vivo target validation in the drug discovery process.
Trends Biotechnol
; 20(1): 36-42, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11742676
ABSTRACT
The completion of the Human Genome Project has signaled the beginning of the post-genome era, with a corresponding shift in focus from the sequencing and identification of genes to the exploration of gene function. A rate-limiting step in deriving value from this gene sequence information is determining the potential pharmaceutical applications of genes and their encoded proteins. This validation step is crucial for focusing efforts and resources on only the most promising targets. Strategies using reverse mouse genetics provide excellent methods for validating potential targets and therapeutic proteins in vivo in a mammalian model system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Engenharia Genética
/
Testes Genéticos
/
Marcação de Genes
/
Avaliação Pré-Clínica de Medicamentos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Trends Biotechnol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos