Heritability and molecular genetic studies of endometriosis.
Ann N Y Acad Sci
; 955: 239-51; discussion 293-5, 396-406, 2002 Mar.
Article
em En
| MEDLINE
| ID: mdl-11949952
Endometriosis is well established as a condition showing heritable tendencies. Polygenic/multifactorial etiology appears far more likely to be the etiology than Mendelian inheritance. The current task is to determine the number and location of genes responsible for endometriosis. This paper shall review the basis for concluding that endometriosis is a genetic disorder of polygenic/multifactorial inheritance and outline selected strategies for identifying the number and location of causative genes. It shall also illustrate our approach to testing the hypothesis that endometriosis bears similarity to neoplasia and, hence, is a multistep phenomenon of clonal origin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Endometriose
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos