[Changes of serotonergic neurons induced by low dose nicotine in rat forebrain].
Nihon Arukoru Yakubutsu Igakkai Zasshi
; 38(2): 103-9, 2003 Apr.
Article
em Ja
| MEDLINE
| ID: mdl-12784661
ABSTRACT
Nicotine has been reported to exert several biological and pharmacological activities in central nervous system. There are many studies on the relationship between dopaminergic neurons and nicotine dependence. However, the relevance between nicotine and serotonergic neurons on dependence remains unknown. We demonstrate here that the effect of continuous low dose nicotine administration on setoronergic neurons (5-HT) immunoreactive fibers and terminals were increased in nicotine (0.5 mg/kg/day, 28 days) treated rat forebrain including anterior cingulate cortex and hippocampus. These results indicate that low dose nicotine, levels of smoking, may be related the developing the dependence of nicotine via the changes of 5-HT neurons in forebrain.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serotonina
/
Prosencéfalo
/
Neurônios
/
Nicotina
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
Ja
Revista:
Nihon Arukoru Yakubutsu Igakkai Zasshi
Assunto da revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão