Susceptibility to amphetamine-induced place preference is predicted by locomotor response to novelty and amphetamine in the mouse.
Psychopharmacology (Berl)
; 172(3): 264-70, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-14600800
ABSTRACT
RATIONALE It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be usefully exploited to dissect behavioral phenotypes related to place conditioning induced by addictive drugs. OBJECTIVES:
This study evaluated a number of behavioral phenotypes related to amphetamine-induced place preference for strain differences (C57BL/6J vs DBA/2J) susceptible to be abolished by temporary food restriction.METHODS:
Mice of the two inbred strains were tested for (1) conditioned taste aversion and place preference induced by amphetamine within the same dose-range; (2) preference for a novel compartment 24 h after a single exposure to only one of two compartments; (3) amphetamine-induced behavioral sensitization and conditioned hyperactivity; and (4) locomotor activity during exploration of a novel environment.RESULTS:
The two strains showed consistent taste aversion at doses of amphetamine that promoted opposite strain-dependent place conditioning. Both strains spent more time exploring the novel rather than the known compartment of the place conditioning apparatus. Instead, only mice of the C57 strain showed amphetamine-induced behavioral sensitization and conditioned hyperactivity. However, temporary food restriction did not affect strain differences for these phenotypes. Finally, C57 mice were more active than DBA in a novel environment and restricted feeding abolished this strain-dependent difference.CONCLUSIONS:
These results relate individual differences for amphetamine-induced place conditioning with locomotor response to amphetamine and novelty.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Condicionamento Psicológico
/
Anfetamina
/
Estimulantes do Sistema Nervoso Central
/
Locomoção
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Itália