The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria.
Bioorg Med Chem Lett
; 14(6): 1423-6, 2004 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-15006375
ABSTRACT
Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Escherichia coli
/
Amidas
/
Aminoácidos
/
Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos