An open-label trial of escitalopram in pervasive developmental disorders.
J Am Acad Child Adolesc Psychiatry
; 44(4): 343-8, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15782081
ABSTRACT
OBJECTIVE:
To assess the effect of escitalopram in the treatment of pervasive developmental disorders (PDDs).METHOD:
This 10-week study had a forced titration, open-label design. Twenty-eight subjects (mean age 125.1 +/- 33.5 months) with a PDD received escitalopram at a dose that increased weekly to a maximum dose of 20 mg as tolerated. The Aberrant Behavior Checklist-Community Version (ABC-CV) and the Clinical Global Impression scale (CGI) were used to assess outcome.RESULTS:
There was significant improvement in ABC-CV Irritability Subscale Scores (baseline mean 20.5 +/- 5.9 to final mean 10.9 +/- 7.2; p < or = .001) and in the other ABC-CV Subscales. Improvement on Clinical Global Improvement Scale severity rating was also significant (baseline mean 5.2 +/- 1.0 to final mean 4.6 +/- 1.2; p < or = .001). Twenty-five percent of the subjects responded at a dose less than 10 mg and did not tolerate the 10-mg dose, and an additional 36% responded at a dose greater than or equal to 10 mg. Final dose was unrelated to weight and only weakly correlated with age.CONCLUSIONS:
This open-label study found escitalopram to be useful in treating some difficulties common in PDDs. A wide variability in dose was found that could not be accounted for by weight and only partially by age. The study provides information useful for the design of double-blind, placebo-controlled studies of escitalopram in PDDs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citalopram
/
Transtornos Globais do Desenvolvimento Infantil
/
Inibidores Seletivos de Recaptação de Serotonina
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Am Acad Child Adolesc Psychiatry
Assunto da revista:
PEDIATRIA
/
PSIQUIATRIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos