Antimitotic properties of pterocarpans isolated from Platymiscium floribundum on sea urchin eggs.
Planta Med
; 71(7): 683-5, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-16041657
This study reports the antimitotic effects on sea urchin eggs of five known pterocarpans: (+)-3,10-dihydroxy-9-methoxypterocarpan, (+)-3,9-dimethoxypterocarpan [(+)-homopterocarpin], (+)-2,3,9-trimethoxypterocarpan, (+)-3,4-dihydroxy-9-methoxypterocarpan [(+)-vesticarpan] and (+)-3-hydroxy-9-methoxypterocarpan [(+)-medicarpin], isolated from the trunk of Platymiscium floribundum, a native tree from Brazil. All tested compounds showed strong activity in this assay, with 2,3,9-trimethoxypterocarpan being the most active (log IC50 of -8.10 +/- 0.02; -7.91 +/- 0.01; -7.97 +/- 0.02 M for first and third cleavages, and blastulae stages, respectively). These data suggest that the 2-methoxy substituent can be an important pharmacophoric unit.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Árvores
/
Extratos Vegetais
/
Fitoterapia
/
Mitose
/
Antineoplásicos Fitogênicos
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil