[Examination of rheumatoid factor and other serum markers in rheumatoid arthritis].
Yakugaku Zasshi
; 125(11): 881-7, 2005 Nov.
Article
em Ja
| MEDLINE
| ID: mdl-16272809
ABSTRACT
Rheumatoid factor (IgM-RF) has been widely used to diagnose rheumatoid arthritis (RA) in clinical practice. We investigated the RA diagnostic performances of anti-cyclic citrullinated peptide antibody (anti-CCP), matrix metalloproteinase-3 (MMP-3), anti-agalactosyl IgG antibody (CA*RF), and anti-calpastatin antibody (ACA) in comparison with IgM-RF. Among 68 RA patients, IgM-RF was positive in 31 (45.6%) and negative in 37 (54.4%). In the IgM-RF-positive group, positivity in anti-CCP, CA*RF, and ACA was 97%, 100%, and 97%, respectively, although that in MMP-3 (74%) was inferior to the others. On the other hand, in the IgM-RF-negative group, positivity in anti-CCP, MMP-3, and ACA was 73%, 81%, and 86%, respectively, although that in CA*RF was only 59%. We conclude that the combination of IgM-RF and anti-CCP/ACA will provide an accurate diagnosis of RA in clinical practice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Artrite Reumatoide
/
Fator Reumatoide
/
Autoanticorpos
/
Proteínas de Ligação ao Cálcio
/
Imunoglobulina M
Tipo de estudo:
Evaluation_studies
Limite:
Humans
Idioma:
Ja
Revista:
Yakugaku Zasshi
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão