A functional hierarchy for c-Myc target genes? Lessons from MT-MC1.
Cell Cycle
; 5(4): 392-3, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16481743
ABSTRACT
Deregulation of CMYC is a hallmark of many human cancers. As a general bHLH-ZIP transcription factor, the c-Myc oncoprotein directly regulates the expression of >1500 genes controlled by RNA polymerases I, II and III. This represents a formidable challenge to determining which are the most critical for transformation. Previous work from our laboratory has indicated that MT-MC1, a direct c-Myc target gene, mimics many c-Myc phenotypes. More recently, genome-wide microarray experiments indicate that MT-MC1 itself regulates fewer than 50 downstream target genes, many of which, if not all, are also c-Myc targets. These observations suggest that this small, overlapping subset of target genes plays a particularly important role in c-Myc-mediated transformation. This is supported by the finding that nearly half of MT-MC1-regulated genes have been previously implicated in cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Proteínas Proto-Oncogênicas c-myc
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Cycle
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos