Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments.
Brain Res
; 1122(1): 179-83, 2006 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-17030027
ABSTRACT
We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reserpina
/
Aprendizagem da Esquiva
/
Inibidores da Captação Adrenérgica
/
Transtornos Parkinsonianos
/
Aprendizagem por Discriminação
/
Transtornos da Memória
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil