Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis.
J Exp Med
; 203(11): 2425-31, 2006 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-17043145
ABSTRACT
Follicular lymphoma is one of the most common adult lymphoma, and remains virtually incurable despite its relatively indolent nature. t(14;18)(q32;q21) translocation, the genetic hallmark and early initiating event of follicular lymphoma (FL) pathogenesis, is also present at low frequency in the peripheral blood of healthy individuals. It has long been assumed that in healthy individuals t(14;18) is carried by circulating quiescent naive B cells, where its oncogenic potential would be restrained. Here, we question this current view and demonstrate that in healthy individuals, t(14;18) is actually carried by an expanding population of atypical B cells issued from germinal centers, displaying genotypic and phenotypic features of FL, and prone to constitute potent premalignant FL niches. These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Subpopulações de Linfócitos B
/
Linfoma Folicular
Limite:
Humans
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
França