Impairments in spatial memory retention of GFAP-apoE4 female mice.
Behav Brain Res
; 176(2): 372-5, 2007 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-17126420
ABSTRACT
The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Espacial
/
Apolipoproteína E4
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Proteína Glial Fibrilar Ácida
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Transtornos da Memória
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos