A randomised study of the effect of two doses of biosynthetic human growth hormone on final height of children with familial short stature.
Horm Res
; 70(2): 89-92, 2008.
Article
em En
| MEDLINE
| ID: mdl-18547955
ABSTRACT
BACKGROUND/AIMS:
The effects of biosynthetic human growth hormone (r-hGH) in children with familial short stature (FSS) are varied. We determined whether responsivity to r-hGH in FSS is dose-dependent.METHOD:
Randomised trial of two doses (20 or 40 IU/m(2) body surface area/week by daily subcutaneous injection) of r-hGH in 29 (24 male, 5 female) FSS children with assessment at adult height.RESULTS:
Age range at presentation was 5.1-10.5 years, height less than 1.5 standard deviation scores (SDS) below the mean, height velocity SDS greater than -1.5 and peak growth hormone response to provocative testing over 13.5 mU/l. Adult height data (SDS) at 16.5 +/- 2.1 years for the low-dose group and 16.1 +/- 1.1 years for the high-dose group (p = 0.62) were similar [low dose -1.06 (SD 0.75), high dose -1.02 (SD 0.83); p = 0.88]. The incremental effect of both doses on stature was minimal [low-dose difference in height actual-predicted 0.79 (SD 0.94), high dose 1.27 (SD 0.88); p = 0.12].CONCLUSION:
Using this r-hGH dosing schedule there were little short- or long-term effects on height in children with FSS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Hormônio do Crescimento Humano
/
Transtornos do Crescimento
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Child
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Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Horm Res
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido