Acylated iridoids with cytotoxicity from Valeriana jatamansi.
J Nat Prod
; 72(4): 650-5, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19245261
ABSTRACT
Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Valeriana
/
Medicamentos de Ervas Chinesas
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Iridoides
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Antineoplásicos Fitogênicos
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2009
Tipo de documento:
Article