Mid-pregnancy androgen levels are negatively associated with breastfeeding.
Acta Obstet Gynecol Scand
; 89(1): 87-94, 2010.
Article
em En
| MEDLINE
| ID: mdl-19900072
ABSTRACT
OBJECTIVE:
Breastfeeding depends on endocrine changes during pregnancy. The association between gestational hormones and lactation has been sparsely investigated. Previously, androgens were used for lactation inhibition. We investigated a possible association between second trimester maternal androgen levels and breastfeeding.DESIGN:
Prospective observational study.SETTING:
University hospital setting. POPULATION. Women from a random sample of pregnancies (n = 63) and from a group with an increased risk for giving birth to a small-for-gestational age newborn (n = 118) were included. All participants had singleton pregnancies and one or two previous births.METHODS:
Maternal androgen levels were measured in gestational week 25. The association with reported breastfeeding was explored by univariate and multivariate linear regression analyses. Analyses were adjusted for factors known to be associated with breastfeeding. MAIN OUTCOMEMEASURES:
Breastfeeding at six weeks, three months, and six months postpartum.RESULTS:
In the random group, breastfeeding at three and six months was negatively associated with maternal testosterone, androstendione, and free testosterone index levels. After correction for maternal age, education and smoking, breastfeeding at both three and six months was negatively associated with the free testosterone index. In the group of women with an increased risk for giving birth to a small-for-gestational age newborn, breastfeeding at six weeks and three months was associated negatively with maternal dehydroepiandrosterone and this association persisted after correction for maternal age, education, and smoking.CONCLUSIONS:
Maternal androgen levels in mid-pregnancy are negatively associated with breastfeeding.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Segundo Trimestre da Gravidez
/
Testosterona
/
Aleitamento Materno
/
Androstenodiona
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Acta Obstet Gynecol Scand
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Noruega