Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.
Postgrad Med
; 122(1): 163-71, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-20107300
ABSTRACT
The prevalence of obesity and diabetes is epidemic. Severe insulin resistance (defined as the need for > or = 200 units of insulin per day to achieve glycemic control) is commonly seen with obesity and can complicate diabetes management. The management of patients with diabetes who have severe insulin resistance is difficult, and at times frustrating, and requires a multifaceted approach. Weight loss is the best treatment option, which can be a challenging task for patients to achieve and maintain. Medications that decrease insulin needs like metformin, thiazolidinediones, or pramlintide may help, but some patients also need high doses of insulin. This article reviews these different treatment options and provides practical advice on weight loss, use of insulin sensitizers, and use of U-500 insulin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Redução de Peso
/
Diabetes Mellitus
/
Obesidade
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Postgrad Med
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos