Perspectives of engineering lactic acid bacteria for biotechnological polyol production.
Appl Microbiol Biotechnol
; 86(4): 1003-15, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20180114
ABSTRACT
Polyols are sugar alcohols largely used as sweeteners and they are claimed to have several health-promoting effects (low-caloric, low-glycemic, low-insulinemic, anticariogenic, and prebiotic). While at present chemical synthesis is the only strategy able to assure the polyol market demand, the biotechnological production of polyols has been implemented in yeasts, fungi, and bacteria. Lactic acid bacteria (LAB) are a group of microorganisms particularly suited for polyol production as they display a fermentative metabolism associated with an important redox modulation and a limited biosynthetic capacity. In addition, LAB participate in food fermentation processes, where in situ production of polyols during fermentation may be useful in the development of novel functional foods. Here, we review the polyol production by LAB, focusing on metabolic engineering strategies aimed to redirect sugar fermentation pathways towards the synthesis of biotechnologically important sugar alcohols such as sorbitol, mannitol, and xylitol. Furthermore, possible approaches are presented for engineering new fermentation routes in LAB for production of arabitol, ribitol, and erythritol.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Bactérias
/
Biotecnologia
/
Engenharia Genética
/
Redes e Vias Metabólicas
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha