Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.
Diabetes Care
; 33(8): 1831-3, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20484128
ABSTRACT
OBJECTIVE:
To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN ANDMETHODS:
A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men by letrozole (aromatase inhibitor) to lower estradiol (E(2)) and increase testosterone (group T, n = 10) versus letrozole plus E(2) patches to lower T and raise E(2) (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period.RESULTS:
Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E.CONCLUSIONS:
In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Triazóis
/
Triglicerídeos
/
Resistência à Insulina
/
Polipeptídeo Inibidor Gástrico
/
Estradiol
/
Metabolismo dos Lipídeos
/
Nitrilas
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Diabetes Care
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Bélgica