Pandemic influenza A (H1N1) 2009: chest radiographic findings from 147 proven cases in the Montreal area.
Can Assoc Radiol J
; 61(4): 233-40, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20510575
ABSTRACT
OBJECTIVE:
To describe chest radiographic findings in patients with isolated and complicated acute novel influenza A (H1N1) virus infection.METHODS:
Retrospective study of 147 patients (64 men, mean age 41) with reverse-transcriptase polymerase chain reaction confirmed acute influenza A (H1N1) infection, who also had a chest radiograph <72 hours of viral specimen collection. Radiographs were analysed for acute findings. A correlation with bacterial cultures results was performed. The unpaired 2-sample equal-variance Student t test was applied to continuous variables and the Pearson χ(2) test of association to discrete variables.RESULTS:
In 71% of cases, chest radiograph was normal. The presence of acute imaging findings was associated with older age (P < .05), increased number of comorbidities (most commonly, chronic obstructive pulmonary disease, diabetes, asthma) (P < .05), higher rate of hospitalization (P < .05) and intensive care unit admission, and increased mortality. Predominant acute radiographic finding in isolated influenza A (H1N1) was alveolar opacity (88%), either unifocal or multifocal, most often in the lower lobes. In the subgroup of patients with positive imaging findings and for whom nonviral microbiologic data was available, 62% had superimposed bacterial or fungal infection.CONCLUSION:
In the majority of patients with acute influenza A (H1N1) infection, the chest radiograph is normal. Acute imaging findings are associated with older age, an increased number of comorbidities, and a higher rate of complications and mortality. The predominant radiographic finding of isolated primary influenza A (H1N1) infection is alveolar opacity. Superimposed bacterial infection is frequent and must be excluded in patients with abnormal imaging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Doença Pulmonar Obstrutiva Crônica
/
Influenza Humana
/
Pulmão
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Can Assoc Radiol J
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Canadá