Regulation of VSMC behavior by the cadherin-catenin complex.
Front Biosci (Landmark Ed)
; 16(2): 644-57, 2011 01 01.
Article
em En
| MEDLINE
| ID: mdl-21196194
ABSTRACT
Vascular smooth muscle cells (VSMCs) are the predominant cell type within blood vessels. In normal vessels VSMC have low rates of proliferation, migration and apoptosis. However, increased VSMC proliferation, migration, and apoptosis rates radically alter the composition and structure of the blood vessel wall and contribute to vascular diseases such as atherosclerosis, in-stent restenosis and vein graft failure. Consequently, therapies that modulate VSMC proliferation, migration and apoptosis may be useful for treating vascular diseases. In this review article we discuss recently emerging research that has revealed that homophilic cell-cell contacts mediated by the cadherincatenin complex and Wnt/beta-catenin signalling are important regulators of VSMC behaviour.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caderinas
/
Beta Catenina
/
Placa Aterosclerótica
/
Músculo Liso Vascular
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido