Papular epidermal nevus with "skyline" basal cell layer (PENS).
J Am Acad Dermatol
; 64(5): 888-92, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21315481
ABSTRACT
BACKGROUND:
Several types of epidermal keratinocytic nevus are recognized.OBJECTIVE:
We sought to describe a previously unreported keratinocytic nevus with distinctive clinical and histopathologic features in 5 patients.METHODS:
We performed a clinical and photographic review, and obtained skin biopsy samples for histopathologic examination from each patient. Genetic analysis to screen for fibroblast growth factor receptor 3 and phosphatidylinositol 3-kinase, catalytic, alpha hotspot mutations was performed on lesional skin from two patients.RESULTS:
Five infants (2 male, 3 female) had from 1 to 11 lesions present since birth. These consisted of 1- to 7-mm hyperkeratotic papules with a rough, flat surface and a round, commalike, rectangular, or polygonal shape. Histopathologic examination showed acanthosis with broad and rectangular rete ridges, and strikingly arranged basal cells with palisaded nuclei. Genetic testing on paraffin-embedded specimens from two patients ruled out hotspot mutations in the fibroblast growth factor receptor 3 and phosphatidylinositol 3-kinase, catalytic, alpha genes.LIMITATIONS:
A small number of patients are presented.CONCLUSION:
We propose the name "papular epidermal nevus with 'skyline' basal cell layer" (PENS) for this newly recognized condition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Nevo
Limite:
Female
/
Humans
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Infant
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Male
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Espanha