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Postchemotherapy surgery for germ cell tumors of the testis.
Carver, Brett S; Sheinfeld, Joel.
Afiliação
  • Carver BS; Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Curr Opin Oncol ; 23(3): 271-4, 2011 May.
Article em En | MEDLINE | ID: mdl-21415749
PURPOSE OF REVIEW: To summarize the surgical management of metastatic germ cell tumors of the testis, highlighting the indications for surgery and controversies surrounding the integration of surgery. RECENT FINDINGS: The multidisciplinary approach to the management of germ cell tumors of the testis has resulted in survival rates of greater than 90% overall. However, controversies exist regarding the surgical management of patients who achieve a complete radiographic response following chemotherapy as well as the appropriate retroperitoneal templates to use in the postchemotherapy setting. Recent data have demonstrated that despite a complete radiographic response, approximately 30% of patients will harbor either viable cancer or teratoma in the retroperitoneum. With advances in nerve-sparing techniques and the probability of disease extending beyond the anatomic boundaries of modified templates, a bilateral nerve-sparing retroperitoneal lymph node dissection is the treatment of choice for patients with metastatic nonseminoma, initially treated with chemotherapy. SUMMARY: Postchemotherapy surgical resection of all sites of residual disease remains a critical component to the multidisciplinary management of metastatic testicular cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Embrionárias de Células Germinativas Limite: Humans / Male Idioma: En Revista: Curr Opin Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Embrionárias de Células Germinativas Limite: Humans / Male Idioma: En Revista: Curr Opin Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos