Does ß-adrenoceptor blocker therapy improve cancer survival? Findings from a population-based retrospective cohort study.
Br J Clin Pharmacol
; 72(1): 157-61, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21453301
ABSTRACT
AIMS:
To examine the effect of ß-adrenoceptor blocker treatment on cancer survival.METHODS:
In a UK primary care database, we compared patients with a new cancer diagnosis receiving ß-adrenoceptor blockers regularly (n= 1406) with patients receiving other antihypertensive medication (n= 2056).RESULTS:
Compared with cancer patients receiving other antihypertensive medication, patients receiving ß-adrenoceptor blocker therapy experienced slightly poorer survival (HR = 1.18, 95% CI 1.04, 1.33 for all ß-adrenoceptor blockers; HR = 1.21, 95% CI 0.94, 1.55 for non-selective ß-adrenoceptor blockers). This poorer overall survival was explained by patients with pancreatic and prostate cancer with no evidence of an effect on survival for patients with lung, breast or colorectal cancer. Analysis in a cancer-free matched parallel cohort did not suggest selection bias masked a beneficial effect.CONCLUSION:
Our study does not support the hypothesis that ß-adrenoceptor blockers improve survival for common cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas Adrenérgicos beta
/
Hipertensão
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Br J Clin Pharmacol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido