Methodological approaches influencing cellular uptake and cyto-(geno) toxic effects of nanoparticles.
J Biomed Nanotechnol
; 7(1): 3-5, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21485774
ABSTRACT
Methods are needed to assess cytotoxicity and genotoxicity of nanoparticles (NPs). The influence of serum and the use of cytochalasin-B were assessed on the cellular uptake of amorphous silica NPs (SNPs) and their biological effects. Our observations indicate that some methodological approaches may modulate the outcome of the assay. Therefore the experimental design and choice of the assays are of great importance in nanotoxicology.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes para Micronúcleos
/
Dióxido de Silício
/
Citotoxinas
/
Testes de Toxicidade Crônica
/
Nanopartículas
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
J Biomed Nanotechnol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Bélgica