Targeted delivery of VEGF to treat myocardial infarction.
Adv Exp Med Biol
; 765: 307-314, 2013.
Article
em En
| MEDLINE
| ID: mdl-22879049
ABSTRACT
Noninvasive injection of pro-angiogenic compounds such as vascular endothelial growth factor (VEGF) has shown promising results in regenerating cardiac microvasculature. However, these results have failed to translate into successful clinical trials in part due to the short half-life of VEGF in circulation. Increasing the dose of VEGF may increase its availability to the target tissue, but harmful side-effects remain a concern. Encapsulating and selectively targeting VEGF to the MI border zone may circumvent these problems. Anti-P-selectin conjugated immunoliposomes containing VEGF were developed to target the infarct border zone in a rat MI model. Targeted VEGF therapy significantly improves vascularization and cardiac function after an infarction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Selectina-P
/
Fator A de Crescimento do Endotélio Vascular
/
Coração
/
Lipossomos
/
Infarto do Miocárdio
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos