Free-amine-directed alkenylation of C(sp2)-H and cycloamination by palladium catalysis.
Chemistry
; 18(49): 15816-21, 2012 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-23055185
ABSTRACT
A new protocol for the palladium-catalyzed free-amine-directed alkenylation of C(sp(2))-H bonds and cycloamination is described. Substituted biaryl-2-amines react with various alkenes, including electron-deficient alkenes, aryl alkenes and alkyl alkenes, to give the corresponding phenanthridines with exclusive regioselectivity. The use of α-branched styrenes leads to the formation of tricyclic compounds with a seven-membered amine ring. The method operates through a free-amine-directed alkenylation and a subsequent hydroamination cyclization reaction.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article