Diabetes mellitus and increased risk of extrahepatic cholangiocarcinoma: a meta-analysis.
Hepatogastroenterology
; 60(124): 684-7, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23321031
ABSTRACT
BACKGROUND/AIMS:
Diabetes mellitus (DM) has been considered to be relevant to an increased risk of several different types of cancers. However, its relationship with extrahepatic cholangiocarcinoma (ECC) remains unclear.METHODOLOGY:
To investigate a quantitative assessment of this relationship, we performed a meta-analysis to evaluate the association between diabetes and the risk of ECC. We identified studies by searching Embase (from 1 January 1974 to 30 June 2012), Medline (from 1 January 1966 to 30 June 2012), and the reference lists of related articles. Summary relative risks (RRs) with corresponding 95% CIs were calculated with a random-effects model.RESULTS:
A total of 9 articles (4 case-control and 5 cohort studies) were included in this study. Compared with those without DM, individuals with DM had an increased risk of ECC (for case-control studies summary OR=1.61, 95% CI 1.05-2.49, p=0.063 for heterogeneity; for cohort studies summary RR=1.61, 95% CI 1.14-2.29, p=0.005 for heterogeneity). The funnel plot showed no evidence for publication bias concerning DM and the risk of ECC (Egger's test, p=0.699; Begg's test, p=0.175).CONCLUSIONS:
These findings strongly reveal the positive link between DM and the increased risk of ECC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
/
Colangiocarcinoma
/
Complicações do Diabetes
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Hepatogastroenterology
Ano de publicação:
2013
Tipo de documento:
Article