A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA.
Adv Healthc Mater
; 2(8): 1120-5, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23386367
ABSTRACT
SS-cleavable proton-activated lipid-like material (ssPalm) functions as a key element in a lipid nanoparticle in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton-sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that can be cleaved in a reducing environment (cytosol).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmídeos
/
DNA
/
Dissulfetos
/
Nanopartículas
Limite:
Humans
Idioma:
En
Revista:
Adv Healthc Mater
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão