The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.
Psychiatry Res
; 209(2): 242-5, 2013 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-23601795
ABSTRACT
We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Antipsicóticos
/
Epilepsia Tônico-Clônica
/
Clozapina
/
Citocromo P-450 CYP1A2
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Psychiatry Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil