Patient-derived tumor xenografts: transforming clinical samples into mouse models.
Cancer Res
; 73(17): 5315-9, 2013 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-23733750
ABSTRACT
Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Modelos Animais de Doenças
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos