Changes of cerebral oxygen metabolism and hemodynamics during ECPR with hypothermia measured by near-infrared spectroscopy: a pilot study.
Adv Exp Med Biol
; 789: 121-128, 2013.
Article
em En
| MEDLINE
| ID: mdl-23852485
ABSTRACT
BACKGROUND:
The 2010 CPR Guidelines recommend that extracorporeal cardiopulmonary resuscitation (ECPR) using an emergency cardiopulmonary bypass (CPB) should be considered for patients with cardiac arrest. However, it is not yet clear whether this therapy can improve cerebral circulation and oxygenation in these patients. To clarify this issue, we evaluated changes of cerebral blood oxygenation (CBO) during ECPR using near-infrared spectroscopy (NIRS).METHODS:
We employed NIRS to measure CBO in the bilateral frontal lobe in patients transported to the emergency room (ER) after out-of-hospital cardiac arrest between November 2009 and June 2011.RESULTS:
Fifteen patients met the above criteria. The tissue oxygenation index (TOI) on arrival at the ER was 36.5 %. This increased to 67.8 % during ECPR (P < 0.001). The one patient whose TOI subsequently decreased had a favorable neurological outcome.CONCLUSION:
Increase of TOI during ECPR might reflect an improvement in cerebral blood flow, while decrease of TOI after ECPR might reflect oxygen utilization by the brain tissue as a result of neuronal cell survival. NIRS may be useful for monitoring cerebral hemodynamics and oxygen metabolism during CPR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Circulação Cerebrovascular
/
Reanimação Cardiopulmonar
/
Cérebro
/
Hipotermia
Tipo de estudo:
Guideline
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão