Inhibition of LRRK2 kinase activity stimulates macroautophagy.

Manzoni, Claudia; Mamais, Adamantios; Dihanich, Sybille; Abeti, Rosella; Soutar, Marc P M; Plun-Favreau, Helene; Giunti, Paola; Tooze, Sharon A; Bandopadhyay, Rina; Lewis, Patrick A

Manzoni, Claudia; Mamais, Adamantios; Dihanich, Sybille; Abeti, Rosella; Soutar, Marc P M; Plun-Favreau, Helene; Giunti, Paola; Tooze, Sharon A; Bandopadhyay, Rina; Lewis, Patrick A.

Afiliação

Manzoni C; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. Electronic address: c.manzoni@ucl.ac.uk.
Mamais A; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK; Reta Lila Weston Institute and Queen Square Brain Bank, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK.
Dihanich S; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Abeti R; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Soutar MPM; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Plun-Favreau H; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Giunti P; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Tooze SA; London Research Institute, Cancer Research UK, Lincoln's Inn Fields, London, WC2A 3LY, UK.
Bandopadhyay R; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK; Reta Lila Weston Institute and Queen Square Brain Bank, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK.
Lewis PA; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK; School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AP, UK. Electronic address: patrick.lewis@ucl.ac.uk.

Biochim Biophys Acta ; 1833(12): 2900-2910, 2013 Dec.

Article em En | MEDLINE | ID: mdl-23916833

Assuntos

Autofagia; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Astrócitos/citologia; Astrócitos/efeitos dos fármacos; Astrócitos/enzimologia; Autofagia/efeitos dos fármacos; Benzodiazepinonas/farmacologia; Linhagem Celular Tumoral; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Imuno-Histoquímica; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina; Lisossomos/efeitos dos fármacos; Lisossomos/metabolismo; Proteínas Associadas aos Microtúbulos; Inibidores de Proteínas Quinases/farmacologia; Proteínas Serina-Treonina Quinases/metabolismo; Transporte Proteico/efeitos dos fármacos; Pirimidinas/farmacologia; Ratos; Proteína Sequestossoma-1

Palavras-chave

C-terminal of ROC domain; COR; DMSO; DPBS; Dimethylsulfoxide; Dulbecco's phosphate buffered saline; EDTA; Ethylene di-ammonium tetra acetic acid; LC3; LRRK2; Leucine Rich Repeat Kinase 2; Macroautophagy; Mammalian target of rapamycin; Parkinson's disease; ROC; Ras of Complex Proteins; SDS; Sodium dodecyl sulphate; WIPI2; mTOR; p62

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas Serina-Treonina Quinases Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2013 Tipo de documento: Article

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