Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms.

Skrzypski, M; Kakkassery, M; Mergler, S; Grötzinger, C; Khajavi, N; Sassek, M; Szczepankiewicz, D; Wiedenmann, B; Nowak, K W; Strowski, M Z

Skrzypski, M; Kakkassery, M; Mergler, S; Grötzinger, C; Khajavi, N; Sassek, M; Szczepankiewicz, D; Wiedenmann, B; Nowak, K W; Strowski, M Z.

Afiliação

Skrzypski M; Department of Hepatology and Gastroenterology, The Interdisciplinary Centre of Metabolism: Endocrinology, Diabetes and Metabolism, Charité-University Medicine Berlin, 13353 Berlin, Germany; Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, 60-637 Poznan, Poland.

FEBS Lett ; 587(19): 3281-7, 2013 Oct 01.

Article em En | MEDLINE | ID: mdl-23999312

Assuntos

Cálcio/metabolismo; Glucose/metabolismo; Insulina/metabolismo; Ilhotas Pancreáticas/metabolismo; Canais de Cátion TRPV/metabolismo; Linhagem Celular; Humanos; Secreção de Insulina

Palavras-chave

4α-PDD; Beta cell; Calcium; INS-1E; Insulin secretion; KRHB; KrebsRinger-HEPES buffer; PKC; TRP; TRPM2; TRPV4; cAMP; cyclic adenosine monophosphate; hIAPP; human islet amyloid polypeptide; non-targeting siRNA; nt siRNA; protein kinase C; siRNA; small interfering RNA; the phorbol ester 4α-phorbol 12,13-didecanoate; transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily M, member 2; transient receptor potential channel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Ilhotas Pancreáticas / Canais de Cátion TRPV / Glucose / Insulina Limite: Humans Idioma: En Revista: FEBS Lett Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Polônia

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