Palladium-catalyzed oxidative acetoxylation of benzylic C-H bond using bidentate auxiliary.
J Org Chem
; 78(21): 10821-31, 2013 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-24106909
ABSTRACT
Pd(OAc)2-catalyzed oxidative acetoxylation of benzylic C-H bonds utilizing a bidentate system has been explored. A variety of picolinoyl- or quinoline-2-carbonyl-protected toluidine derivatives react with PhI(OAc)2 in the presence of Pd(OAc)2 to afford the acetoxylated products in synthetically useful yields. A broad of functionalities, such as CH3, F, Cl, Br, I, COCH3, CO2Et, SO2CH3, and NO2, were tolerated. This transformation provides easy access to 2-hydroxymethylaniline derivatives.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Compostos de Benzil
/
Compostos de Anilina
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China