Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast.
Biochem Biophys Res Commun
; 441(1): 236-42, 2013 Nov 08.
Article
em En
| MEDLINE
| ID: mdl-24141116
ABSTRACT
Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.
Palavras-chave
ATP; CLS; CR; CRMs; Caloric restriction; Caloric restriction mimetics; MMP; Mitochondrial membrane potential; RLS; ROS; Rapamycin; Reactive oxygen species; caloric restriction; caloric restriction mimetics; chronological lifespan; mitochondrial membrane potential; reactive oxygen species; replicative lifespan
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Restrição Calórica
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Mitocôndrias
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2013
Tipo de documento:
Article