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Cell biological steps and checkpoints in accessing NK cell cytotoxicity.
Mace, Emily M; Dongre, Prachi; Hsu, Hsiang-Ting; Sinha, Papiya; James, Ashley M; Mann, Shaina S; Forbes, Lisa R; Watkin, Levi B; Orange, Jordan S.
Afiliação
  • Mace EM; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Dongre P; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Hsu HT; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Sinha P; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • James AM; Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Mann SS; Case Western Reserve Medical School, Cleveland, OH, USA.
  • Forbes LR; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Watkin LB; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Orange JS; Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Immunol Cell Biol ; 92(3): 245-55, 2014 Mar.
Article em En | MEDLINE | ID: mdl-24445602
Natural killer (NK) cell-mediated cytotoxicity is governed by the formation of a lytic immune synapse in discrete regulated steps, which give rise to an extensive array of cellular checkpoints in accessing NK cell-mediated cytolytic defense. Appropriate progression through these cell biological steps is critical for the directed secretion of specialized secretory lysosomes and subsequent target cell death. Here we highlight recent discoveries in the formation of the NK cell cytolytic synapse as well as the molecular steps and cell biological checkpoints required for this essential host defense process.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Citotoxicidade Imunológica / Pontos de Checagem do Ciclo Celular Limite: Animals / Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Citotoxicidade Imunológica / Pontos de Checagem do Ciclo Celular Limite: Animals / Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos