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Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Han, Seungil; Czerwinski, Robert M; Caspers, Nicole L; Limburg, David C; Ding, WeiDong; Wang, Hong; Ohren, Jeffrey F; Rajamohan, Francis; McLellan, Thomas J; Unwalla, Ray; Choi, Chulho; Parikh, Mihir D; Seth, Nilufer; Edmonds, Jason; Phillips, Chris; Shakya, Subarna; Li, Xin; Spaulding, Vikki; Hughes, Samantha; Cook, Andrew; Robinson, Colin; Mathias, John P; Navratilova, Iva; Medley, Quintus G; Anderson, David R; Kurumbail, Ravi G; Aulabaugh, Ann.
Afiliação
  • Han S; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Czerwinski RM; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Caspers NL; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Limburg DC; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Ding W; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Wang H; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Ohren JF; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Rajamohan F; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • McLellan TJ; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Unwalla R; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Choi C; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Parikh MD; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Seth N; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Edmonds J; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Phillips C; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Shakya S; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Li X; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Spaulding V; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Hughes S; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Cook A; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Robinson C; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Mathias JP; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Medley QG; †Pfizer Worldwide Research, 200 Cambridge Park Drive, Cambridge, MA 02140, U.S.A.
  • Anderson DR; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Kurumbail RG; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
  • Aulabaugh A; *Pfizer Worldwide Research, Eastern Point Road, Groton, CT 06340, U.S.A.
Biochem J ; 460(2): 211-22, 2014 Jun 01.
Article em En | MEDLINE | ID: mdl-24593284
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos