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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Dusonchet, Julien; Li, Hu; Guillily, Maria; Liu, Min; Stafa, Klodjan; Derada Troletti, Claudio; Boon, Joon Y; Saha, Shamol; Glauser, Liliane; Mamais, Adamantios; Citro, Allison; Youmans, Katherine L; Liu, LiQun; Schneider, Bernard L; Aebischer, Patrick; Yue, Zhenyu; Bandopadhyay, Rina; Glicksman, Marcie A; Moore, Darren J; Collins, James J; Wolozin, Benjamin.
Afiliação
  • Dusonchet J; Department of Pharmacology and Experimental Therapeutics and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA, Howard Hughes Medical Institute, Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, US
  • Li H; Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
  • Guillily M; Department of Pharmacology and Experimental Therapeutics and.
  • Liu M; Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women's Hospital, Cambridge, MA 02139, USA.
  • Stafa K; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Derada Troletti C; Department of Pharmacology and Experimental Therapeutics and.
  • Boon JY; Department of Pharmacology and Experimental Therapeutics and.
  • Saha S; Department of Pharmacology and Experimental Therapeutics and.
  • Glauser L; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Mamais A; Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, WC1N 1PJ, UK.
  • Citro A; Department of Pharmacology and Experimental Therapeutics and.
  • Youmans KL; Department of Pharmacology and Experimental Therapeutics and.
  • Liu L; Department of Pharmacology and Experimental Therapeutics and.
  • Schneider BL; Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Aebischer P; Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Yue Z; Department of Neurology and Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Bandopadhyay R; Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, WC1N 1PJ, UK.
  • Glicksman MA; Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women's Hospital, Cambridge, MA 02139, USA.
  • Moore DJ; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Collins JJ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA, Howard Hughes Medical Institute, Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, USA, bwolozin@bu.edu jcollins@bu.edu.
  • Wolozin B; Department of Pharmacology and Experimental Therapeutics and Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA, bwolozin@bu.edu jcollins@bu.edu.
Hum Mol Genet ; 23(18): 4887-905, 2014 Sep 15.
Article em En | MEDLINE | ID: mdl-24794857
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Serina-Treonina Quinases / Proteínas RGS / Redes Reguladoras de Genes / Neurônios Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Serina-Treonina Quinases / Proteínas RGS / Redes Reguladoras de Genes / Neurônios Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos