Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study.
Clin Genet
; 88(2): 167-71, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25041097
ABSTRACT
Tooth agenesis is one of the most common congenital anomalies in humans. However, the etiology of tooth agenesis remains largely unclear, as well as evidence base useful for genetic counseling. Therefore, we estimated the prevalence and sibling recurrence risk, and investigated agenetic patterns systematically. Tooth agenesis was classified into two subtypes hypodontia (one to five missing teeth) and oligodontia (six or more missing teeth). The prevalence of these two subtypes were 6.8% [95% confidence interval (CI) 6.1-7.7%] and 0.1% (95% CI 0.04-0.3%), respectively, and sibling recurrence risk of these were 24.5% (95% CI 13.8-38.3%) and 43.8% (95% CI 26.4-62.3%), respectively. This result suggests that the severe phenotype, oligodontia, might be mostly transmitted in a dominant fashion. Using a simple statistical modeling approach, our data were found to be consistent with a bilateral symmetry model, meaning that there was equal probability of missing teeth from the right and left sides.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epidemiologia Molecular
/
Anodontia
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Clin Genet
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão