Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.

Zha, Weibin; Edin, Matthew L; Vendrov, Kimberly C; Schuck, Robert N; Lih, Fred B; Jat, Jawahar Lal; Bradbury, J Alyce; DeGraff, Laura M; Hua, Kunjie; Tomer, Kenneth B; Falck, John R; Zeldin, Darryl C; Lee, Craig R

Zha, Weibin; Edin, Matthew L; Vendrov, Kimberly C; Schuck, Robert N; Lih, Fred B; Jat, Jawahar Lal; Bradbury, J Alyce; DeGraff, Laura M; Hua, Kunjie; Tomer, Kenneth B; Falck, John R; Zeldin, Darryl C; Lee, Craig R.

Afiliação

Zha W; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC.
Edin ML; Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Vendrov KC; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC.
Schuck RN; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC.
Lih FB; Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Jat JL; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.
Bradbury JA; Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
DeGraff LM; Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Hua K; UNC Nutrition Obesity Research Center, University of North Carolina, Chapel Hill, NC.
Tomer KB; Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Falck JR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.
Zeldin DC; Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Lee CR; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC.

J Lipid Res ; 55(10): 2124-36, 2014 Oct.

Article em En | MEDLINE | ID: mdl-25114171

Assuntos

Adipogenia/efeitos dos fármacos; Sistema Enzimático do Citocromo P-450; Eicosanoides/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Intolerância à Glucose/tratamento farmacológico; Obesidade/tratamento farmacológico; Células 3T3-L1; Adipogenia/genética; Animais; Gorduras na Dieta/administração & dosagem; Gorduras na Dieta/efeitos adversos; Intolerância à Glucose/induzido quimicamente; Intolerância à Glucose/genética; Intolerância à Glucose/metabolismo; Intolerância à Glucose/patologia; Camundongos; Camundongos Knockout; Obesidade/induzido quimicamente; Obesidade/genética; Obesidade/metabolismo; Obesidade/patologia

Palavras-chave

adipose tissue; arachidonic acid; eicosanoids; high-fat diet; metabolomics; soluble epoxide hydrolase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eicosanoides / Regulação da Expressão Gênica / Intolerância à Glucose / Sistema Enzimático do Citocromo P-450 / Adipogenia / Obesidade Limite: Animals Idioma: En Revista: J Lipid Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Nova Caledônia

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