Epigenetic inactivation of transforming growth factor-ß1 target gene HEYL, a novel tumor suppressor, is involved in the P53-induced apoptotic pathway in hepatocellular carcinoma.

Kuo, Kung-Kai; Jian, Shu-Fang; Li, Yi-Jin; Wan, Shi-Wei; Weng, Ching-Chieh; Fang, KuanTe; Wu, Deng-Chyang; Cheng, Kuang-Hung

Kuo, Kung-Kai; Jian, Shu-Fang; Li, Yi-Jin; Wan, Shi-Wei; Weng, Ching-Chieh; Fang, KuanTe; Wu, Deng-Chyang; Cheng, Kuang-Hung.

Afiliação

Kuo KK; Department of Surgery, Division of Hepatobiliary Pancreatic Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jian SF; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Li YJ; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Wan SW; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Weng CC; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Fang K; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Wu DC; Department of Research and Development, Eternal Chemical, Kaohsiung, Taiwan.
Cheng KH; Division of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Hepatol Res ; 45(7): 782-93, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25179429

Palavras-chave

HEYL; P53; apoptosis; hepatocellular carcinoma; promoter hypermethylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Hepatol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan

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