Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.

Cho, Hyun Jin; Yu, Jia; Xie, Chengsong; Rudrabhatla, Parvathi; Chen, Xi; Wu, Junbing; Parisiadou, Loukia; Liu, Guoxiang; Sun, Lixin; Ma, Bo; Ding, Jinhui; Liu, Zhihua; Cai, Huaibin

Cho, Hyun Jin; Yu, Jia; Xie, Chengsong; Rudrabhatla, Parvathi; Chen, Xi; Wu, Junbing; Parisiadou, Loukia; Liu, Guoxiang; Sun, Lixin; Ma, Bo; Ding, Jinhui; Liu, Zhihua; Cai, Huaibin.

Afiliação

Cho HJ; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Yu J; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Xie C; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Rudrabhatla P; Laboratory of Neurochemistry and Laboratory of Neurobiology National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Chen X; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Wu J; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Parisiadou L; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Liu G; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Sun L; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Ma B; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA.
Ding J; Bioinformatics Core, Laboratory of Neurogenetics National Institute on Aging, Bethesda, MD, USA.
Liu Z; Laboratory of Immunology, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, MD, USA Institute of Biophysics Chinese Academy of Sciences, Beijing, China zhihualiu@ibp.ac.cn caih@mail.nih.gov.
Cai H; Transgenics Section, Laboratory of Neurogenetics National Institute on Aging National Institutes of Health, Bethesda, MD, USA zhihualiu@ibp.ac.cn caih@mail.nih.gov.

EMBO J ; 33(20): 2314-31, 2014 Oct 16.

Article em En | MEDLINE | ID: mdl-25201882

Assuntos

Retículo Endoplasmático/metabolismo; Complexo de Golgi/metabolismo; Doença de Parkinson/enzimologia; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas de Transporte Vesicular/metabolismo; Animais; Vesículas Revestidas pelo Complexo de Proteína do Envoltório/metabolismo; Linhagem Celular; Células Cultivadas; Espinhas Dendríticas/metabolismo; Regulação da Expressão Gênica; Genes Reporter; Humanos; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina; Camundongos; Modelos Biológicos; Mutação de Sentido Incorreto; Mapeamento de Interação de Proteínas; Proteínas Serina-Treonina Quinases/genética; Transporte Proteico; Proteínas Recombinantes de Fusão; Proteínas de Transporte Vesicular/genética

Palavras-chave

ER exit sites (ERES); ERGolgi transport; Leucinerich repeat kinase 2 (LRRK2); Sec16A; dendritic ERES (dERES)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Serina-Treonina Quinases / Proteínas de Transporte Vesicular / Retículo Endoplasmático / Complexo de Golgi Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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