Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.

Büller, Nikè V J A; Rosekrans, Sanne L; Metcalfe, Ciara; Heijmans, Jarom; van Dop, Willemijn A; Fessler, Evelyn; Jansen, Marnix; Ahn, Christina; Vermeulen, Jacqueline L M; Westendorp, B Florien; Robanus-Maandag, Els C; Offerhaus, G Johan; Medema, Jan Paul; D'Haens, Geert R A M; Wildenberg, Manon E; de Sauvage, Frederic J; Muncan, Vanesa; van den Brink, Gijs R

Büller, Nikè V J A; Rosekrans, Sanne L; Metcalfe, Ciara; Heijmans, Jarom; van Dop, Willemijn A; Fessler, Evelyn; Jansen, Marnix; Ahn, Christina; Vermeulen, Jacqueline L M; Westendorp, B Florien; Robanus-Maandag, Els C; Offerhaus, G Johan; Medema, Jan Paul; D'Haens, Geert R A M; Wildenberg, Manon E; de Sauvage, Frederic J; Muncan, Vanesa; van den Brink, Gijs R.

Afiliação

Büller NV; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Rosekrans SL; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Metcalfe C; Molecular Oncology Department, Genentech, South San Francisco, California.
Heijmans J; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
van Dop WA; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Fessler E; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands.
Jansen M; Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ahn C; Molecular Oncology Department, Genentech, South San Francisco, California.
Vermeulen JL; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Westendorp BF; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Robanus-Maandag EC; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Offerhaus GJ; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Medema JP; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands.
D'Haens GR; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Wildenberg ME; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
de Sauvage FJ; Molecular Oncology Department, Genentech, South San Francisco, California.
Muncan V; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
van den Brink GR; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: g.r.vandenbrink@amc.nl.

Gastroenterology ; 148(1): 170-180.e6, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25307863

Assuntos

Adenoma/metabolismo; Biomarcadores Tumorais/metabolismo; Transformação Celular Neoplásica/metabolismo; Proteínas Hedgehog/metabolismo; Neoplasias Intestinais/metabolismo; Transdução de Sinais; Células Estromais/metabolismo; Adenoma/induzido quimicamente; Adenoma/genética; Adenoma/patologia; Polipose Adenomatosa do Colo/metabolismo; Polipose Adenomatosa do Colo/patologia; Animais; Comunicação Autócrina; Biomarcadores Tumorais/genética; Estudos de Casos e Controles; Proliferação de Células; Transformação Celular Neoplásica/genética; Transformação Celular Neoplásica/patologia; Citocromo P-450 CYP1A1/genética; Modelos Animais de Doenças; Células Epiteliais/metabolismo; Células Epiteliais/patologia; Regulação Neoplásica da Expressão Gênica; Genes APC; Predisposição Genética para Doença; Proteínas Hedgehog/genética; Humanos; Hiperplasia; Integrases/genética; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patologia; Neoplasias Intestinais/induzido quimicamente; Neoplasias Intestinais/genética; Neoplasias Intestinais/patologia; Camundongos Transgênicos; Mutação; Comunicação Parácrina; Fenótipo; RNA Mensageiro/metabolismo; Células Estromais/patologia; Carga Tumoral; beta-Naftoflavona

Palavras-chave

COX2; Colon Cancer; Mouse Model; Prostaglandin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Biomarcadores Tumorais / Adenoma / Transformação Celular Neoplásica / Células Estromais / Proteínas Hedgehog / Neoplasias Intestinais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Gastroenterology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda

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