Temporal lobe impairment in West syndrome: event-related potential evidence.
Ann Neurol
; 77(1): 47-57, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25363285
ABSTRACT
OBJECTIVE:
This study investigates auditory processing in infants with West syndrome (WS) using event-related potentials (ERPs).METHODS:
ERPs were measured in 25 infants with mainly symptomatic WS (age range = 3-10 months) and 26 healthy term infants (age range = 3-9 months) using an auditory novelty oddball paradigm. The ERP recordings were made during wakefulness and repeated in stage II sleep.RESULTS:
The obligatory components (P150, N250, P350) and novelty response components (P300, Nc) were recordable during both sleep and wakefulness in patients and controls. All ERP latencies decreased with age in controls but not in the WS group (age × group interaction, F = 22.3, p < 0.0001). These ERP latency alterations were not affected by pharmacological treatment for WS.INTERPRETATION:
This study demonstrated a persistently altered ERP signature in patients with a recent history of infantile spasms. The prolongation of auditory obligatory and novelty ERPs in WS patients indicates a severe failure of temporal lobe maturation during infancy. It remains to be investigated whether this predicts long-term cognitive impairments characteristic for this epileptic encephalopathy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espasmos Infantis
/
Lobo Temporal
/
Potenciais Evocados Auditivos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2015
Tipo de documento:
Article