Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury.

Li, Ying; Korgaonkar, Akshata A; Swietek, Bogumila; Wang, Jianfeng; Elgammal, Fatima S; Elkabes, Stella; Santhakumar, Vijayalakshmi

Li, Ying; Korgaonkar, Akshata A; Swietek, Bogumila; Wang, Jianfeng; Elgammal, Fatima S; Elkabes, Stella; Santhakumar, Vijayalakshmi.

Afiliação

Li Y; Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Korgaonkar AA; Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Graduate School of Biomedical Sciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Swietek B; Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Wang J; Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Elgammal FS; Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Elkabes S; Graduate School of Biomedical Sciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Santhakumar V; Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Graduate School of Biomedical Sciences, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Department of Pharmacology and Physiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Neurobiol Dis ; 74: 240-53, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25497689

Assuntos

Concussão Encefálica/fisiopatologia; Giro Denteado/fisiopatologia; Neurônios/fisiologia; Receptores de N-Metil-D-Aspartato/metabolismo; Potenciais Sinápticos/fisiologia; Receptor 4 Toll-Like/metabolismo; Animais; Giro Denteado/efeitos dos fármacos; Modelos Animais de Doenças; Progressão da Doença; Antagonistas de Aminoácidos Excitatórios/farmacologia; Ácido Glutâmico/metabolismo; Masculino; Neurônios/efeitos dos fármacos; Ratos Wistar; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Potenciais Sinápticos/efeitos dos fármacos; Fatores de Tempo; Técnicas de Cultura de Tecidos; Receptor 4 Toll-Like/agonistas; Receptor 4 Toll-Like/antagonistas & inibidores

Palavras-chave

AMPA; Dentate gyrus; Electrophysiology; Excitability; Hippocampus; Innate immune response; Mossy cell; NMDA; Traumatic brain injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Concussão Encefálica / Receptores de N-Metil-D-Aspartato / Giro Denteado / Receptor 4 Toll-Like / Potenciais Sinápticos / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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