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Immunohistochemical expression of p53, p63, c-myc, p21(WAF1/cip1) and p27(kip1) proteins in urothelial bladder carcinoma: correlation with clinicopathological parameters.
Grapsa, Dimitra; Dokou, Anna; Tsokanou-Kouli, Vassiliki; Kaltsas, Serafim; Dalakou, Eleftheria; Trigidou, Rodoula; Saif, Muhammad W; Politi, Ekaterini.
Afiliação
  • Grapsa D; Oncology Unit, 3rd Department of Medicine, "Sotiria" General Hospital, Athens School of Medicine, Athens, Greece.
J BUON ; 19(4): 1121-4, 2014.
Article em En | MEDLINE | ID: mdl-25536625
PURPOSE: To reevaluate the expression levels of p53, p63, c-myc, p21(WAF1/cip1) and p27(kip1) proteins and their potential association with standard clinicopathological parameters, including tumor stage and grade, in urothelial bladder carcinoma (UBC). METHODS: Immunohistochemistry was performed in 100 transurethral resection specimens obtained from prospectively identified patients with primary UBC. RESULTS: Overall, 26, 41 and 75% of the cases showed positive staining for p53, p63 and c-myc, respectively, while p21(WAF1/cip1) and p27(kip1) expression levels were altered in 75 and 88% of the cases, respectively. Positive staining for p53 was associated with increased tumor stage (pT2) (p=0.037), while altered expression of p27(kip1) was strongly associated with male gender (p=0.009). CONCLUSION: The results of our study imply that p53 overexpression may be a useful marker of tumor invasion in UBC. In contrast, we failed to demonstrate any statistically significant correlation between the remaining markers evaluated and tumor stage or grade.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma de Células de Transição / Proteína Supressora de Tumor p53 Limite: Female / Humans / Male Idioma: En Revista: J BUON Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Grécia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Carcinoma de Células de Transição / Proteína Supressora de Tumor p53 Limite: Female / Humans / Male Idioma: En Revista: J BUON Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Grécia