Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1&#945;.

Flannigan, Kyle L; Agbor, Terence A; Motta, Jean-Paul; Ferraz, José G P; Wang, Rui; Buret, Andre G; Wallace, John L

Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α.

Flannigan, Kyle L; Agbor, Terence A; Motta, Jean-Paul; Ferraz, José G P; Wang, Rui; Buret, Andre G; Wallace, John L.

Afiliação

Flannigan KL; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
Agbor TA; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
Motta JP; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
Ferraz JG; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
Wang R; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
Buret AG; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
Wallace JL; *Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Departments of Biological Sciences, Medicine, and Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; and Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada altapharm@hotmail.co

FASEB J ; 29(4): 1591-602, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25550470

Assuntos

Colite/metabolismo; Sulfeto de Hidrogênio/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Compostos Alílicos/farmacologia; Animais; Benzenossulfonatos/toxicidade; Colite/tratamento farmacológico; Colite/patologia; Cistationina gama-Liase/antagonistas & inibidores; Cistationina gama-Liase/metabolismo; Modelos Animais de Doenças; Dissulfetos/farmacologia; Expressão Gênica; Células HT29; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/antagonistas & inibidores; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Compostos de Mostarda/farmacologia; Fenilpropionatos/farmacologia; Estabilidade Proteica; Ratos; Ratos Wistar; Cicatrização/efeitos dos fármacos; Cicatrização/fisiologia

Palavras-chave

gasotransmitter; healing; inflammation; inflammatory bowel disease; ulcer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Subunidade alfa do Fator 1 Induzível por Hipóxia / Sulfeto de Hidrogênio Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá

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